Can getting a vaccination cause an allergy?
I think this is an obvious item. Can getting a vaccination cause an allergy? Not cause an allergic reaction to the shot but cause a peanut allergy if the vaccine has peanut oil in it?
First, let’s examine how a vaccine works.
http://www.immunisation.nhs.uk/Vaccines/Hib_Men_C/Vaccine/How_does_the_vaccine_work
The vaccine works by causing the body to produce its own protection (antibodies) against these bacteria.
Simple. The vaccine causes the body to create antibodies against the bacteria in the vaccine.
Ok, now let’s examine what an allergy is.
http://www.allernet.com/ALLABOUT/index.html
The allergy antibody (IgE) made by your immune system is produced in response to your exposure to substances we refer to as ALLERGENS. Allergens are usually environmentally stable foreign substances like pollen proteins that may induce unfortunate allergy immune reactions in predisposed individuals.
Is IgE important to the immune response? Or is it solely an allergic response?
http://www.sunstar.com.ph/static/bag/2005/01/16/oped/dr..vic.dumaguing.html
we have our antibodies, which are produced by so-called plasma cells. These antibodies are of the gamma globulin type proteins. Otherwise called immunoglobulins (Ig), they complement our white blood cells in combating infections. Thus, IgM or immunoglobulin M is the first antibody that would meet an invading microbe, together with neutrophil.
Likewise, the longer-lasting IgG takes over if the battle lasts longer. IgG is also the most common antibody our bodies produced in response to vaccination or immunization. Breast-fed infants get abundant supply of IgA from their mothers and also IgG while they were still inside the womb. IgE pairs with eosinophil in controlling parasitic infestations.
Looks like IgE is important to the body’s immunity in controlling parasitic infestations. Couldn’t find anything else on the net about what IgE is supposed to do for the body. But it is a natural thing for the body to produce and important so we do want it.
OK, now have there been any people or animal studies that showed a direct cause and effect between vaccine and food allergy?
http://www.vran.org/vaccines/anaphylaxis/vaccine-ana.htm
J Allergy Clin Immunol 2001 Apr;107(4):693-702 Murine model of atopic dermatitis associated with food hypersensitivity states, “Female C3H/HeJ mice were sensitized orally to cow’s milk or peanut with a cholera toxin adjuvant and then subjected to low-grade allergen exposure………………..An eczematous eruption developed in approximately one third of mice after low-grade exposure to milk or peanut proteins……………….This eczematous eruption resembles AD (atopic dermatitis) in human subjects and should provide a useful model for studying immunopathogenic mechanisms of food hypersensitivity in AD.” PMID 11295660
Allergy 1978 Jun:33(3):155-9 Aluminum phosphate but not calcium phosphate stimulates the specific IgE response in guinea pigs to tetanus toxoid. It is hypothesized that the regular application of aluminum compound-containing vaccines on the entire population could be one of the factors leading to the observed increase of allergic diseases. PMID 707792
Pediatric Allergy Immunol 1994 May;5(2):118-23 Immunoglobulin E and G responses to pertussis toxin after booster immunization in relation to atopy, local reactions and aluminum content of the vaccines. The role of aluminum for IgG and IgE responses to pertussis toxin (PT), as well as for side effects, was investigated in 49 children with known atopy status………………the addition of aluminum to the pertussis vaccine was, thus, associated with a stronger IgG antibody response, but tended also to induce a stronger IgE antibody response. The correlation between total IgE and PT-IgE, which was most prominent in children with atopy, indicates that the role of immunization for the development of allergy merits further studies. PMID 808719
http://lrsitbrd.nic.in/IJTB/Year%201990/October%201990/october%201990%20D.pdf
A PILOT STUDY TO ASSESS POST VACCINATION ALLERGY INDUCED
AFTER BCG VACCINATION IN INFANTS VACCINATED BY AUXILIARY
NURSE-MIDWIVES IN AJMER (RAJASTHAN)
Yet, the observed mean size of post-vaccination allergy in both the groups was below 6 mm i.e. much lower than what could be expected. Since the maximum extent of post-vaccination allergy occurs three to four months following vaccination, the possible waning of allergy, if any, that could have occurred in the two to three months that elapsed after the target timing could not have been so profound.
http://www.chiroweb.com/mpacms/dc/article.php?id=31598
Do DTP and Tetanus Vaccinations Cause Asthma?
New Study Shows Vaccinated Children Twice as Likely to Get Asthma and Other Allergy-Related Symptoms
By Michael Devitt
A new study in the Journal of Manipulative and Physiological Therapeutics1 supports the findings of three previous studies that children who receive diphteria-tetanus-pertussis (DTP) or tetanus vaccines are more likely to have a “history of asthma” or other “allergy-related respiratory symptoms.” The study reviewed data from the Third National Health and Nutrition Examination Survey, which was conducted by the National Center for Health Statistics from 1988 to 1994.
http://www.vaccination.inoz.com/asthma3.html
Michel Odent20 found the frequency of asthma in a group of fully vaccinated children to be 11%, while a 1997 NZ study21 found 23%. Both found the frequency in the unvaccinated children to be only 0 – 1%. Several studies have found the rate higher after vaccines that use aluminum hydroxide as adjuvants in the postnatal period.22
Significantly, there was a decrease in deaths from asthma in the U.S. for some years until the DPT vaccine was mandated in the U.S. for school entry, in 1978. Since then, deaths from asthma23 and other immune disorders have been rising (as has also the reported incidence of whooping cough itself!).
20 JAMA 1994;272 (8): pgs 592-3, and Lancet 1994:344:140.
21 Epidemiology 1997 Nov 8:6 678-80
22 J Allergy Clin Immunol 1999;104:1128-30. Dec 1999; 104 Number 6
23 CDC MMWR reports (See Appendix B in Submission article on this web site)
http://content.karger.com/ProdukteDB/produkte.asp?
Aktion=ShowFulltext&ArtikelNr=112498&Ausgabe=234225&ProduktNr=224161
A Neonatal Swine Model of Allergy Induced by the Major Food Allergen Chicken Ovomucoid (Gal d 1)
Methods: In order to induce Ovm sensitivity, piglets at days 14, 21 and 35 of age were sensitized by intraperitoneal injection of 100 µg of crude Ovm and cholera toxin (50, 25 or 10 µg). Controls received 50 µg of cholera toxin in phosphate-buffered saline.
http://findarticles.com/p/articles/mi_m1200/is_/ai_104730216
Brandt and his colleagues induced an allergy to chicken eggs in a group of mice by injecting them with ovalbumin, an egg protein. Then they fed the mice ovalbumin, placed within coated pill-like beads to prevent the protein’s destruction in the stomach. The mice became unable to digest food, a sign that they were suffering a severe allergic reaction. A control group of mice that weren’t allergic to ovalbumin showed no signs of distress when fed the beads.
http://medical-dictionary.thefreedictionary.com/induced+allergy
definition: induced allergy
allergy resulting from the injection of an antigen, contact with an antigen, or infection with a microorganism, as contrasted with hereditary allergy.
Inflammatory Responses in Skin and Airways after Allergen Challenge in Brown Norway Rats Sensitized to Trimellitic Anhydride.
Abstract:
Trimellitic anhydride (TMA) is a low-molecular-weight compound which causes occupational allergy. Brown Norway rats were sensitized to TMA injected intradermally (0.3% TMA suspended in oil). Three weeks later, we examined responses to either free TMA injected intradermally, or TMA conjugated to rat serum albumin (TMA-RSA) given by inhalation (0.5% nebulized for 15 min). Twenty-one days after the sensitization, …Sensitized animals showed significantly higher levels of specific IgG and IgE. We conclude that brown Norway rats can be used as a model of TMA-induced allergic inflammation, mimicking occupational asthma.
(C) 1996 Munksgaard International Publishers Ltd.
From preview of the book
Samter’s Immunologic Diseases
By Karl Frank Austen
In 1902, Charles Richet and Paul Portier reported that, whereas the extract from sea anemone tentacles had no effect on dogs when given as a signel injection, a second injection after a few weeks caused arapid and fatal reaction. Richet gave the term anaphylaxis to this phenomenon suggesting that the initial injection of toxin had somehow weakened the dog’s defense mechanisms and increased its susceptibility to toxin on subsequent exposure.
Reported pertussis infection and risk of atopy in 8- to 12-yr-old vaccinated and nonvaccinated
children.
1. Original ArticlePediatric Allergy & Immunology. 19(1):46-52, February 2008.
Bernsen, Roos M. D. 1, 2; Nagelkerke, Nico J. D. 2; Thijs, Carel 3; van der Wouden, Johannes
C. 1
Abstract:
Pertussis infection has been suspected to be a potential causal factor in the development of atopic disease because of the effect of pertussis immunization on specific IgE antibodies. Although several studies found a positive association between pertussis infection and atopic disorders, this relationship has not yet been studied in a population stratified by vaccination status. To assess the association between pertussis infection and atopic disorders in pertussis-unvaccinated children and in pertussis-vaccinated children. Using data from a previously conducted study on the relationship between the diphtheria-tetanus-pertussis-(inactivated) poliomyelitis vaccination in the first year of life and atopic disorders, the study population of 1872 8-12 yr old was divided into children pertussis-unvaccinated and children pertussis-vaccinated in the first year of life. Within each group, the association between pertussis infection and atopic disorders (both as reported by the parents) was assessed. In the unvaccinated group, there were no significant associations between pertussis infection and atopic disorders. In the vaccinated group, all associations between pertussis infection and atopic disorders were positive, the associations with asthma [odds ratio (OR) = 2.24, 95% confidence interval (CI95%): 1.36-3.70], hay fever (OR = 2.35, CI95%: 1.46-3.77) and food allergy (OR = 2.68, CI95%: 1.48-4.85) being significant. There was a positive association between pertussis infection and atopic disorders in the pertussis vaccinated group only. From the present study, it cannot be concluded whether this association is causal or due to reverse causation.
Conclusion:
I think it is very clear that a vaccination can cause an allergy.
One Response to 'Can getting a vaccination cause an allergy?'
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on January 17th, 2009 at 9:42 am
I am amazed with it. It is a good thing for my research. Thanks